Standard of care axSpA

Overview

Striving for and achieving high treatment targets is linked to substantial benefits for your SpA patients in terms of:

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Quality of life

Patients who achieve higher ASAS40 improvements also achieve better results in outcomes not included in the ASAS score, such as HRQol, SF-36 PCS, fatigue and nocturnal spinal pain, irrespective of previous treatment status1,2

Structural progression

Achieving lower ASDAS scores is associated with lower spinal progression; an increase of one ASDAS unit is expected to lead to an increase of 0.72 mSASSS units over the next two years³

Patient function

Patients who achieve ASAS40 experience improved engagement and productivity on the job and are better able to perform daily, non-work-related activities compared to ASAS40 non-responders²

Quality of life

Higher ASAS responses correlate with improved quality of life outcomes in AS/r-axSpA patients

Patients who achieve higher ASAS improvements also achieve better results in outcomes not included in the ASAS score. These include outcomes such as HRQoL, SF-36 PCS, fatigue and nocturnal spinal pain, irrespective of previous treatment status.1,2

Association between ASAS20 and ASAS40 and LSM improvement from baseline across different quality of life outcomes1
axSpA/Quality of life
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Speak with a member of our medical team.

If you have questions or want to know more, please reach out to our medical team.

References
1
Adapted from Mease P et al. Rheumatol Ther. 2019;6(3):435–450.
2
Adapted from van der Heijde D et al. Rheumatology. 2016;55(1):80–88.
3
Adapted from Ramiro S et al. Ann Rheum Dis. 2014;73(8):1455–1461
Acronyms
AS
ankylosing spondylitis
ASAS
Assessment of Spondyloarthritis international Society
ASAS20/40
ASAS 20/40% response criteria
ASDAS
Ankylosing Spondylitis Disease Activity Score
axSpA
axial spondyloarthritis
bDMARD
biological disease modifying antirheumatic drug
HRQoL
Health-Related Quality of Life
LSM
Least Square Mean
mSASSS
modified Stoke Ankylosing Spondylitis Spine Score
nr-axSpA
non-radiographic axial spondyloarthritis
NRS
Numerical Rating Scale
PCS
Physical Component Summary
r-axSpA
radiographic axial spondyloarthritis
SF-36
36-Item Short Form Survey
SpA
spondyloarthritis
TNFi
tumour necrosis factor inhibitor
WPAI
Work Productivity and Activity Impairment