Pathobiology
Spondyloarthritis pathobiology is complex
There are many clinically validated targets involved in spondyloarthritis pathobiology, including IL-17, TNF, IL-12, IL-23 and JAK/STAT. Here, we focus on extracellular cytokine targets IL-17, TNF, IL-12 and IL-23.¹
The role of extracellular cytokine targets in SpA pathobiology
There are many clinically validated targets involved in spondyloarthritis pathobiology, including IL-17, TNF, IL-12, IL-23 and JAK/STAT. Although the relative contributions of each are complex, important distinctions are emerging about which cytokines contribute to the various clinical manifestations and SpA disease phenotypes.2,3,9,10,11 Emerging studies are revealing a new dimension of complexity in the IL-17 pathway that may help explain its in vivo functions.12
What is the role of the different cytokines in the IL-17 family?
Whilst different in structure, IL-17A and IL-17F have a very similar biological function.13 IL-17A and IL-17F combine to form homo- and heterodimers.14
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- APC
- antigen-presenting cell
- axSpA
- axial spondyloarthritis
- CCL
- C-C motif chemokine ligand
- CNS
- central nervous system
- G-CSF
- granulocyte colony-stimulating factor
- IL
- interleukin
- ILC
- innate lymphoid cell
- JAK
- Janus kinase
- MAIT
- mucosal-associated invariant T cell
- PsA
- psoriatic arthritis
- STAT
- signal transducer and activator of transcription
- Th
- T helper cell
- TNF
- tumour necrosis factor